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APS is due to autoantibodies that cause blood clots, these clots can also cause strokes, pulmonary embolism and deep vein thrombosis

Relevant roles of each specific IGFBPs will be further discussed when applicable to metabolism since there is a huge emerging world of IGFBPs independent actions

Allin KH, Friedrich N, Pietzner M et al (2017) Genetic determinants of serum vitamin B12 and their relation to body mass index

Vitamin B12 deficiency often develops slowly, and sometimes the symptoms can be easily overlooked, like fatigue, brain fog, or tingling in the hands and feet